From interviewing other designers in the past, good voice talent isn't something you skimp on if that's the direction you go. It adds a layer of immersion that pines for the same level of attention by the player as a good set of visuals; it breathes life into the character and adds conveyed emotion.
Opting to be your own only voice actor is your choice but I'd suggest heavily against it. Even in some Anime titles where the same VA is used between two characters, the audience if paying half attention can pick it out.
From experience in music production and DJing, you will be recognized with effect masks because of the reliance on them to change sound for you. Masks just alter the outside of a natural sound or completely destroy it. You're sounding like you want to manipulate the sound itself.
Watch how artists create the tones for dubstep and glitch, or maybe find the you tube version of the VAs being interviewed while working on God of War 3 - the voice for Kratos talks about a few of the challenges when playing different characters - and you'll see why what you're talking about isn't really what it sounds like you're after.
VA is an underrated talent. Too few people understand how challenging the field is and how much effort and control is required for success.